出羽・近藤研究室
教授/Professor 出羽 毅久 / Takehisa DEWA
国立大学法人 名古屋工業大学
生命・応用化学科/専攻
共同ナノメディシン科学専攻
〒466-8555 名古屋市昭和区御器所町
takedewa*nitech.ac.jp(*=@)
Phone:052-735-5144｜Web
所属
生命・応用化学専攻（生命・物質科学分野）
共同ナノメディシン科学専攻
略歴
| 平成6年 | 東京工業大学理工学研究科博士後期課程（高分子工学専攻）修了 博士（工学） |
| 平成6年 | 米国Lehigh University 博士研究員 (Professor Steven L. Regen) |
| 平成8年 | 科学技術振興事業団CREST研究員（九州大学 青山安宏 教授） |
| 平成13年 | 名古屋工業大学工学部応用化学科 助手 |
| 平成13年 | 科学技術振興事業団 戦略的創造研究さきがけ21研究員（｢組織化と機能｣領域）兼任 |
| 平成15年 | 名古屋工業大学大学院工学研究科 講師 |
| 平成20年 | 名古屋工業大学大学院工学研究科 未来材料創成工学専攻 准教授 |
| 平成21年 | 科学技術振興機構さきがけ研究員（｢光エネルギーと物質変換｣領域）兼任 |
| 平成28年 | 名古屋工業大学大学院 生命・応用化学専攻/共同ナノメディシン科学専攻 教授 |
研究テーマ
生体分子の集合構造と機能相関
- 光合成膜タンパク質の集合構造ー機能相関
- 光合成膜タンパク質の人工系への応用
- ポリアミン脂質を用いた核酸デリバリーシステム
主要論文(2010-現在）
名工大・研究者詳細（別ページが開きます）
- Delivery of external proteins into the cytoplasm using protein capsules modified with IgG on the surface, created from the amphiphilic two helix-bundle protein OLE-ZIP
Kousuke Takahashi, Taiki Nishiyama, Naoki Umezawa, Yasumichi Inoue, Isamu Akiba, Takehisa Dewa, Atsushi Ikeda and Toshihisa Mizuno
Chem. Commun., 60, 968 – 971 (2024) - Functional Coupling of Biohybrid Photosynthetic Antennae and Reaction Center Complexes: Quantitative Comparison with Native Antennae
Takehisa Dewa, Komei Kimoto, Genki Kasagi, Hiromi Harada, Ayumi Sumino, and Masaharu Kondo
J. Phys. Chem. B 127, 10315−10325 (2023) doi: 10.1021/acs.jpcb.3c04922 November 28, 2023 - Cryogenic single-molecule fluorescence detection of mid-infrared response of an intrinsic pigment in light-harvesting complex
Kohei Otomo, Takehisa Dewa, Michio Matsushita, and Satoru Fujiyoshi
J. Phys. Chem. B. 127, 4959−4965 (2023).10.1021/acs.jpcb.3c00284 - Atomic force microscopic analysis of the light-harvesting complex 2 from purple photosynthetic bacterium Thermochromatium tepidum
Masayuki Morimoto, Haruna Hirao, Masaharu Kondo, Takehisa Dewa, Yukihiro Kimura, Zheng-Yu Wang-Otomo, Hitoshi Asakawa, Yoshitaka Saga
Photosynth. Res. 157, 13-20 (2023). 10.1007/s11120-023-01010-4 - Determination of FRET Orientation Factor between Artificial Fluorophore and Photosynthetic Light-Harvesting 2 Complex (LH2)
Kazuhiro J. Fujimoto, Tomoya Miyashita, Takehisa Dewa, Takeshi Yanai,
Sci. Rep. 12, 15091(1-14) (2022). doi.org/10.1038/s41598-022-19375-2 - Energy Transfer Dynamics and Mechanism of Biohybrid Photosynthetic Antenna Complexes Chemically-Linked with Artificial Chromophores
Yusuke Yoneda, Tomoyasu Noji, Naoto Mizutani, Daiji Kato, Masaharu Kondo, Hiroshi Miyasaka, Yutaka Nagasawa, Takehisa Dewa
Phys. Chem. Chem. Phys. 24, 24714-24726 (2022).10.1039/d2cp02465a - Easy preparation of a liposome-mediated protein delivery system by freeze-thawing a liposome–protein complex
Koide, H.; Ochiai, H.; Suzuki, H.; Hirata, S.; Watanabe, M.; Yonezawa, S; Dewa, T.; Oku, N.; Asai, T.
J. Mater. Chem. B 10, 6768-6776 (2022) 10.1039/d2tb00271j - Ultrafast energy transfer between self-assembled fluorophore and photosynthetic light-harvesting complex 2 (LH2) in lipid bilayer
Y. Yoneda, M. Kito, D. Mori, A. Goto, M. Kondo, H. Miyasaka, Y. Nagasawa, T. Dewa
J. Chem. Phys. 156, 095101 (2022). 10.1063/5.0077910 - Direct Energy Transfer from Allophycocyanin-Free Rod-Type CpcL-Phycobilisome to Photosystem I
Tomoyasu Noji, Mai Watanabe, Takehisa Dewa, Shigeru Itoh, Masahiko Ikeuchi
J. Phys. Chem. Lett. 12, 6692−6697 (2021). 10.1021/acs.jpclett.1c01763 - Synthesis of MoS2 Layers on GaN Using Ammonium Tetrathiomolybdate for Heterojunction Device Applications
Pradeep Desai, Bhagyashri Todankar, Ajinkya K. Ranade, Masaharu Kondo, Takehisa Dewa, Masaki Tanemura, and Golap Kalita
Crystal Research and Technology, 2000198 (2021). - Membrane properties of ether-type phosphatidylcholine bearing partially fluorinated C18-monoacetylenic chains and their applicability to membrane protein reconstitution matrices
Teruhiko Baba, Toshiyuki Takagi, Kimio Sumaru, Toshiyuki Kanamori, Takehisa Dewa, Mamoru Nango
Colloids and Surfaces B: Biointerfaces, 198, 111459 (2021) - Photocatalytic activity of the light-harvesting complex of photosystem II (LHCII) monomer
Masaharu Kondo, Haruka Matsuda, Tomoyasu Noji, Mamoru Nango, and Takehisa
Dewa J. Photochem. Photobiol. A: Chemistry, 405, 112926 (2021). 10.1016/j.jphotochem.2020.112926 - Enhanced Light Harvesting and Photocurrent Generation Activities of Biohybrid
Light–harvesting 1–Reaction Center Core Complexes (LH1-RCs) from Rhodopseudomonas
palustris
Genki Kasagi, Yusuke Yoneda, Masaharu Kondo, Hiroshi Miyasaka, Yutaka Nagasawa, Takehisa Dewa
J. Photochem. Photobiol. A: Chemistry, in press - Ultrafast Photodynamics and Quantitative Evaluation of Biohybrid Photosynthetic
Antenna and Reaction Center Complexes Generating Photocurrent
Y. Yoneda, A. Goto, N. Takeda, H. Harada, M. Kondo, H. Miyasaka, Y. Nagasawa, T. Dewa
J. Phys. Chem. C 124, 8605-8615 (2020) - Sequential Energy Transfer Driven by Monoexponential Dynamics in a Biohybrid
Light–Harvesting Complex 2 (LH2)
Y. Yoneda, D. Kato, M. Kondo, K. V. P. Nagashima, H. Miyasaka, Y. Nagasawa, T. Dewa
Photosynth. Res. 143, 115-128 (2020) - Key determinants of siRNA delivery mediated by unique pH-responsive lipid-based
liposomes
Sako M, Song F, Okamoto A, Koide H, Dewa T, Oku N, Asai T
Int. J Pharm. 569, 118606 (2019) - Engineering the binding kinetics of synthetic polymer nanoparticles for
siRNA delivery
H. Koide, T. Fukuta, A. Okishim, S. Ariizumi, C. Kiyokawa, H. Tsuchida, M. Nakamoto, K. Yoshimatsu, H. Ando, T. Dewa, T. Asai, N. Oku, Y. Hoshino, K. J. Shea
Biomacromolecules 20, 3648–3657 (2019) - Rigorous control of vesicle-forming lipid pKa by fluorine-conjugated bioisosteres
for gene-silencing with siRNA
A. Okamoto, H. Koide, N. Morita, Y. Hirai, Y. Kawato, H. Egami, Y. Hamashima, T. Asai, T. Dewa, N. Oku
J. Control. Release 295, 87-92 (2019) - Design of a Novel PEGylated Liposomal Vector for Systemic Delivery of siRNA
to Solid Tumors
F. Song, N. Sakurai, A. Okamoto, H. Koide, N. Oku, T. Dewa, T. Asai
Biol. Pharm. Bull. 42, 996–1003 (2019) - Photovoltaic Action in Graphene-Ga2O3 Heterojunction with Deep-Ultraviolet
Irradiation
G. Kalita, R. D. Mahyavanshi, P. Desai, A. K. Ranade, M. Kondo, T. Dewa, M. Tanemura
Phys. Status Solidi RRL 2018, 12, 1800198 (May 30, 2018) - Selective immobilization of bacterial light-harvesting proteins and their
photoelectric responses
R. Furukawa, M. Kondo, S. Yajima, K. Harada, K. V. P. Nagashima, M. Nagata, K. Iida, T. Dewa, M. Nango
MRS Communications 8, (3), 1124-1128 (2018) - Photovoltaic action with broad band photoresponsivity in germanium-MoS2
ultrathin heterojunction
R. D. Mahyavanshi, G. Kalita, A. Ranade, P. Desai, M. Kondo, T. Dewa, M. Tanemura
IEEE Transactions on Electron Devices, 65, 4434-4440 (2018) - Lipid-Controlled Stabilization of Charge-Separated States (P+QB–) and Photocurrent
Generation Activity of a Light-Harvesting–Reaction Center Core Complex
(LH1-RC) from Rhodopseudomonas palustris
T. Noji, M. Matsuo, N. Takeda, A. Sumino, M. Kondo, M. Nango, S. Itoh, T. Dewa
J. Phys. Chem. B 122, 1066–1080 (2018) - Synthesis of MoS2 ribbons and their branched structures by chemical vapor
deposition in sulfur enriched environment
Mahyavanshi, R. D.; Kalita, G.; Sharma, K. P.; Kondo, M.; Dewa, T.; Kawahara, T.; Tanemura, M
Appl. Surf. Sci. 409, 396-402 (2017) - Encapsulation of transition metal dichalcogenides crystals with room temperature
plasma deposited carbonaceous films
Mahyavanshi, Rakesh D.; Kalita, Golap; Singh, Rupesh; Kondo, Masaharu; Dewa, Takehisa; Kawahara, Toshio; Umeno, Masayoshi; Tanemura, Masaki
RSC Adv. 7, 41136-41143 (2017) - Non-RVD mutations that enhance the dynamics of the TAL repeat array along
the superhelical axis improve TALEN genome editing efficacy
Naoya Tochio, Kohei Umehara, Jun-ichi Uewaki, Holger Flechsig, Masaharu Kondo, Takehisa Dewa, Tetsushi Sakuma, Takashi Yamamoto, Takashi Saitoh, Yuichi Togashi, Shin-ichi Tate
Scientific Reports 2016, 6, 37887 (1-12) - Morphological Observation of Specific Condensation Effect of Cholesterol
on Dipalmitoyl Phosphatidyl Choline (DPPC) Monolayer by Dropping Method
Y. Yokoyama, D. Yoshida, H. Mori, M. Okabe, Z. Shervani, K. Taga, Y. Yamamoto, A. Sumino, T. Dewa, M. Nango, M. Yamamoto
J. Biophys. Chem. 7, 98–109 (2016) - Oxygen-Evolving Porous Glass Plates Containing the Photosynthetic Photosystem
II Pigment-Protein Complex
T. Noji, K. Kawakami, J. R. Shen, T. Dewa, M. Nango, N. Kamiya, S. Itoh, T. Jin
Langmuir, 32, 7796–7805, 2016 - Design of New Extraction Surfactants for Membrane Proteins from Peptide
Gemini Surfactants
M. Shibata, S. Koeda, T. Noji, K. Kawakami, Y. Ido, Y. Amano, N. Umezawa, T. Higuchi, T. Dewa, S. Itoh, N. Kamiya, T. Mizuno
Bioconjugate Chem., 27 (10) 2469-2479 (2016) - Rational design of novel high molecular weight solubilization surfactants
for membrane proteins from the peptide Gemini surfactants (PG-surfactants)
S. Koeda, T. Suzuki, T. Noji, K. Kawakami, S. Itoh, T. Dewa, N. Kamiya, T. Mizuno
Tetrahedron 72, 6898–6908 (2016) - Light-induced hydrogen production by Photosystem I–Pt nanoparticle conjugates
immobilized in porous glass plate nanopores
T. Noji, T. Suzuki, M. Kondo, T. Jin, K. Kawakami, T. Mizuno, H. Oh-oka, M. Ikeuchi, M. Nango, Y. Amao, N. Kamiya, T. Dewa
Res. Chem. Intermed. 42 (11) 7731-7742 (2016) - Light-energy conversion systems for hydrogen production and photocurrent
generation using zinc chlorin derivatives
S. Ishigure, M. Kondo, T. Dewa, Y. Amao, M. Nango
Res. Chem. Intermed. 42 (11) 7743-7752 (2016) - Enhanced efficacy of doxorubicin by microRNA-499-mediated improvement of
tumor blood flow
Ayaka Okamoto, Tomohiro Asai, Sho Ryu, Hidenori Ando, Noriyuki Maeda, Takehisa Dewa, Naoto Oku
Clinical Medicine 5, 10-18 (2016) - Light-induced hydrogen production by Photosystem I–Pt nanoparticle conjugates
immobilized in porous glass plate nanopores
T. Noji, T. Suzuki, M. Kondo, T. Jin, K. Kawakami, T. Mizuno, H. Oh-oka, M. Ikeuchi, M. Nango, Y. Amao, N. Kamiya, T. Dewa
Res. Chem. Intermed. 42 (11) 7731-7742 (2016) - One-step encapsulation of siRNA between lipid-layers of multi-layer polycation
liposomes by lipoplex freeze-thawing
H. Koide, A. Okamoto, H. Tsuchida, H. Ando, S. Ariizumi, C. Kiyokawa, M. Hashimoto, T. Asai, T. Dewa, N. Oku
J. Controlled Release 228, 1-8 2016 - Extension of Light-Harvesting Ability of Photosynthetic Light-Harvesting
Complex 2 (LH2) through Ultrafast Energy Transfer from Covalently Attached
Artificial Chromophores
Y. Yoneda, T. Noji, T. Katayama, N. Mizutani, D. Komori, M. Nango, H. Miyasaka, S. Itoh, Y. Nagasawa, T. Dewa
J. Am. Chem. Soc., 137, 13121-13129 (2015) - Advanced cancer therapy by integrative antitumor actions via systemic administration
of miR-499
H. Ando, T. Asai, H. Koide, A. Okamoto, N. iMaeda, K. Tomita, T. Dewa, T. Minamino, N. Oku
J. Controlled Release 181, 32-39 (2014) - Light-driven Hydrogen Production by Hydrogenases and a Ru-complex inside
a Nanoporous Glass Plate under Aerobic External Conditions
T. Noji, M. Kondo, T. Jin, T. Yazawa, H. Osuka, Y. Higuchi, M. Nango, S. Itoh, T. Dewa
J. Phys. Chem. Lett. 5, 2402–2407 (2014) - Gating-Associated Clustering−Dispersion Dynamics of the KcsA Potassium
Channel in a Lipid Membrane
A. Sumino, D. Yamamoto, M. Iwamoto, T. Dewa, S. Oiki
J. Phys. Chem. Lett. 5, 578-584 (2014) - Structure–Function Relationships of the Supramolecular Assembly of the
Bacterial Photosynthetic Antenna Complexes in Lipid Membranes
T. Dewa, A. Sumino, N. Watanabe, T. Noji, M. Nango
Res. Chem. Intermed. 40, 3243-3256 (2014) - Influence of Phospholipid Composition on Self-Assembly and Energy-Transfer
Efficiency in Networks of Light-Harvesting 2 Complexes
A. Sumino, T. Dewa, T. Noji, Y. Nakano, N. Watanabe, R. Hildner, N. Bösch, J. Köhler, M. Nango
J. Phys. Chem. B 117, 10395–10404 (2013) - Electron Conduction and Photocurrent Generation of a Light-Harvesting/Reaction
Center Core Complex in Lipid Membrane Environments
A. Sumino, T. Dewa, N. Sasaki, M. Kondo, M. Nango
J. Phys. Chem. Lett. 4, 1087–1092 (2013) - Energy Transfer and Clustering of Photosynthetic Light-Harvesting Complexes
in Reconstituted Lipid Membranes
T. Dewa, A. Sumino, N. Watanabe, T. Noji, M. Nango
Chem. Phys., 419, 200-204 (2013) - The Open Gate Structure of the Membrane-Embedded KcsA Potassium Channel
Viewed From the Cytoplasmic Side
A. Sumino, T. Sumikama, M. Iwamoto, T. Dewa, S. Oiki
Scientific Reports 3, 1063 (2013) - Immobilization and Photocurrent Activity of a Light-Harvesting Antenna
Complex II, LHCII Isolated from a Plant on Electrodes
M. Nagata, M. Amano, T. Joke, K. Fuji, A. Okuda, M. Kondo, S. Ishigure, T. Dewa, K. Iida, F. Secundo, Y. Amao, H. Hashimoto, M. Nango
ACS Macro Lett., 1, 296-299 (2012) - RGD-based active targeting of novel polycation liposomes bearing siRNA
for cancer treatment
N. Yonenaga, E. Kenjo, T. Asai, A. Tsuruta, K. Shimizu, T. Dewa, M. Nango, N. Oku
J. Control. Release 160, 177-181 (2012) - Construction and Structural Analysis of Tethered Lipid Bilayer Containing
Photosynthetic Antenna Proteins for Functional Analysis
A. Sumino, T. Dewa, T. Takeuchi, R. Sugiura, N. Sasaki, N. Misawa, R. Tero, T. Urisu, A. T. Gardiner, R. J. Cogdell, H. Hashimoto, M. Nango
Biomacromolecules, 12, 2850-2858 (2011) - Dicetyl phosphate-tetraethylenepentamine-based Liposomes for Systemic siRNA
Delivery
T. Asai, S. Matsushita, E. Kenjo, T. Tsuzuku, N. Yonenaga, H. Koide, K. Hatanaka, T. Dewa, M. Nango, N. Maeda, H. Kikuchi, N. Oku
Bioconjugate Chem. 22 429-435 (2011) - Reconstitution and AFM Observation of Photosynthetic Membrane Protein Assembly
in Planar Lipid Bilayers
A. Sumino, T. Dewa, N. Sasaki, N. Watanabe, M. Kondo, T. Morii, H. Hashimoto, M. Nango
e-J. Surf. Sci. Nanotech. 9, 15-20 (2011) (Editor’s choice) - Selective Assembly of Photosynthetic Antenna Proteins into a Domain-Structured
Lipid Bilayer for the Construction of Artificial Photosynthetic Antenna
Systems: Structural Analysis of the Assembly using Surface Plasmon Resonance
and Atomic Force Microscopy
A. Sumino, T. Dewa, M. Kondo, T. Morii, H. Hashimoto, A. T. Gardiner, R. J. Cogdell, M. Nango
Langmuir, 27, 1092-1099 (2011) - Liposomal Polyamine–Dialkyl Phosphate Conjugates as Effective Gene Carriers:
Chemical Structure, Morphology, and Gene Transfer activity
T. Dewa, T. Asai, Y. Tsunoda, K. Kato, D. Baba, M. Uchida, A. Sumino, K. Niwata, T. Umemoto, K. Iida, N. Oku, M. Nango
Bioconjugate Chem., 21, 844-852 (2010)
