掲載論文・業績

論文

2017

  • “Construction of Enzyme-encapsulated Fibermats from the Cross-linkable Copolymers Poly(acrylamide)-co-poly(diacetone acrylamide) with the Bi-functional Cross-linker, Adipic Acid Dihydrazide”

    Y. Ido, A. L. B. Maçon, M. Iguchi, Y. Ozeki, S. Koeda, A. Obata, T. Kasuga, T. Mizuno*

    Polymer 132, 342-352 (2017).

    “Electrospun Poly(γ-glutamate)/Silica Hybrids for Tissue Regeneration:Influences of Silane Coupling Agents on Chemistry, Degradation and Florescent Dye Release”

    A. Obata, M. Shimada, M. Iguchi, N. Iwanaga, T. Mizuno, T. Kasuga

    Int. J. Metallurg. Mater. Eng. 3, 134 (2017).

    “Construction of DNAzyme-Encapsulated Fibermats Using the Precursor Network Polymer of Poly(γ-glutamate) and 4-Glycidyloxypropyl Trimethoxysilane”

    Koji Mizuno, Shuhei Koeda, Akiko Obata, Jun Sumaoka, Toshihiro Kasuga, Julian R. Jones, Toshihisa Mizuno*

    Langmuir 33, 4028-4035 (2017).

2016

  • “Rational Design of Novel High-Molecular-Weight Solubilization Surfactants for Membrane Proteins from the peptide gemini surfactants (PG-surfactants)”

    S. Koeda, T. Suzuki, T. Noji, K. Kawakami, Y. Ido, T. Dewa, S. Itoh, N. Kamiya, T. Mizuno*

    Tetrahedron, 72, 6898-6908 (2016).

  • “Design of New Extraction Surfactants for Membrane Proteins from Peptide-Gemini Surfactants (PG-surfactants)”

    M. Shibata, S. Koeda, T. Noji, K. Kawakami, Y. Ido, Y. Amano, N. Umezawa, T. Higuchi, T. Dewa, S. Itoh, N. Kamiya, T. Mizuno*

    Bioconjugate Chemistry, 27, 2469-2479 (2016).

    “Construction and Characterization of Protein-Encapsulated Electrospun Fibermats Prepared from a Silica/Poly(γ-glutamate) Hybrid”

    S. Koeda, K. Ichiki, N. Iwanaga, K. Mizuno, M. Shibata, A. Obata, T. Kasuga, T. Mizuno*

    Langmuir, 32(1), 221-229 (2016).

  • ”Fabrication and in vitro Characterization of Electrospun Poly (γ-glutamic acid)-Silica Hybrid Scaffolds for Bone Regeneration”

    C. Gao, S. Ito, A. Obata, T. Mizuno, J. R. Jones, T. Kasuga

    Polymer, 91, 106-117 (2016).

  • “Light-induced hydrogen production by Photosystem I?Pt nanoparticle conjugates immobilized in porous glass plate nanopores”

    T. Noji, T. Suzuki, M. Kondo, T. Jin, K. Kawakami, T. Mizuno, H. Oh-oka, M. Ikeuchi, M. Nango, Y. Amao, N. Kamiya, T. Dewa

    Res. Chem. Intermed., 42, 7731-7742 (2016).

2014

  • “Poly(γ-glutamic acid)-Silica Hybrids with Fibrous Structure: Effect of Cation and Silica Concentration on Molecular Structure, Degradation Rate and Tensile Properties”

    A. Obata, S. Ito, N. Iwanaga, T. Mizuno, J. R. Jones, T. Kasuga

    RSC advances, 4(1), 52491-52499 (2014).

2013

  • “Creation of cross-linked bilayer membranes that can incorporate membrane proteins from oligo-Asp-based PG-surfactants”

    S. Koeda, K. Umezaki, A. Sumino, A. Ikeda, Y. Yamamoto, T. Dewa, K. Taga, M. Nango, T. Tanaka, T. Mizuno

    Langmuir, 29(34), 11695-11704 (2013).

  • “Creation of fibrous nanotube of green fluorescent protein by conjugation with pH-responsive polymer, poly (2-vinylpyridine), and use of a microfluidic synthesis”

    N. Okiyama, E. Ota, A. Sumino, T. Noji, K. Yamamoto, J. Oku, T. Dewa, T. Tanaka, T. Mizuno

    Chem. Lett., 42(5), 495-497 (2013).

  • “Applications of Peptide Gemini Surfactants as Solubilization Surfactants for Photosystems I and II of Cyanobacteria”

    S. Koeda, K. Umezaki, T. Noji, A. Ikeda, K. Kawakami, M. Kondo, Y. Yamamoto, J. Shen, K. Taga, T. Dewa, M. Nango, T. Tanaka, T. Mizuno

    Langmuir , 29(37), 11667-11680 (2013).

  • “Molecular Assembly of Chlorophyll Derivatives Using Recombinant Light-Harvesting Polypeptides with His-tag and Its Immobilization on a Gold Electrode”

    S. Sakai, T. Noji, M. Kondo, T. Mizuno, T. Dewa, T. Ochiai, H. Yamakawa, S. Itoh, H. Hashimoto, M. Nango

    Langmuir, 29, 5104-5109 (2013).

2012

  • “Formation of Planar Bilayer Membranes on Solid Supports Using Peptide Gemini Surfactants”

    K. Umezaki, S. Sakai, S. Koeda, Y. Yamamoto, M. Kondo, A. Ikeda, T. Dewa, K. Taga, T. Tanaka, T. Mizuno

    Chem. Lett., 41, 1430-1432 (2012).

  • “Overexpression of Rhodobacter sphaeroides PufX bearing maltose-binding protein and its effect on the stability of reconstituted light-harvesting core antenna complex”

    S. Sakai, A. Hiro, M. Kondo, T. Mizuno, T. Tanaka, T. Dewa, M. Nango

    Photosynthesis Research, 111(1-2), 63-69 (2012).

2011

  • “Atomic force microscopy of the molecular assembly of the photosynthetic core antenna light harvesting (LH)1-type complex composed of the recombinant LH1-a peptide bearing the maltose-binding protein”

    S. Sakai, A. Sumino, A. Hiro, T. Mizuno, T. Dewa, T. Tanaka, H. Hashimoto, M. Nango

    Chem. Lett., 40, 1280-1282 (2011).

ページの先頭へ

2009

  • “Reconstitution of the Light-harvesting (LH1) Complex Using Zinc-substituted Bacteriochlorophyll a and LH1-polypeptides Isolated from the Purple Photosynthetic Bacterium Rhodospirillum rubrum, Together with all-trans Carotenoids”

    K. Nakagawa, T. Nakano, N. Fukui, A. Nakashima, S. Sakai, T. Mizuno, T. Dewa, K. Iida, A. T. Gardiner, R. J. Cogdell, R. Fujii, H. Hashimoto, M. Nango

    Carotenoid Science, 14, 54-57 (2009).

  • “Reconstitution of the Light-harvesting 1 (LH1) Complex Using LH1-? and LH-1-? Polypeptides, Separately Isolated from the Purple Photosynthetic Bacterium Rhodospirillum rubrum, Together with Bacteriochlorophyll a and All-trans Carotenoids”

    K. Nakagawa, T. Nakano, N. Fukui, A. Nakashima, S. Sakai, T. Mizuno, T. Dewa, K. Iida, A. T. Gardiner, R. J. Cogdell, R. Fujii, H. Hashimoto, M. Nango

    Carotenoid Science, 14, 58-61 (2009).

  • “Carotenoid Specificity During Reconstitution of the Light-harvesting 1 (LH1) Complexes Using LH1-polypeptides Isolated from the Purple Photosynthetic Bacterium Rhodobacter sphaeroides Together with Bacteriochlorophyll a and Carotenoids”

    K. Nakagawa, N. Fukui, T. Nakano, A. Mizuno, A. Nakashima, S. Sakai, T. Mizuno, T. Dewa, K. Iida, A. T. Gardiner, R. J. Cogdell, R. Fujii, H. Hashimoto, M. Nango

    Carotenoid Science, 14, 62-65 (2009).

  • “Organic Ligand Binding by Hydrophobic Cavity in Designed Tetrameric Coiled-Coil Proteins”

    T. Mizuno, C. Hasegawa, Y. Tanabe, K. Hamajima, T. Muto, Y. Nishi, M. Oda, Y. Kobayashi, T. Tanaka

    Chem. Eur. J., 15, 1491-1498 (2009).

  • “Manipulation of the Protein-complex function by using an Engineered Heterotrimeric Coiled-coil Switch”

    T. Mizuno, K. Suzuki, T. Imai, Y. Furutani, M. Kudou, M. Oda, H. kandori, K. Tsumoto, T. Tanaka

    Org. Biomol. Chem., 7, 3102-3111 (2009).

  • “The effect of the side chain length of Asp and Glu on coordination structure of Cu (2+) in a de novo designed protein”

    D. Shiga, D. Nakane, T. Inomata, H. Matsuda, M. Oda, M. Noda, S. Uchiyama, K. Fukui, Y. Takano, H. Nakamura, T. Mizuno, T. Tanaka

    Biopolymer, 91, 907-916 (2009).

  • “Target-selective vesicle fusion system with pH-selectivity and responsiveness”

    A. Kashiwada, M. Tsuboi, T. Mizuno, T. Nagasaki, K. Matsuda

    Soft Matter., 5, 4719-4725 (2009).

2008

  • “Construction of a pH-Responsive Artificial Membrane Fusion System by Using Designed Coiled-Coil Polypeptides”

    A. Kashiwada, K. Matsuda, T. Mizuno, T. Tanaka

    Chem. Eur. J., 14, 7343-7350 (2008).

  • “Regulation of protein-protein interaction via assembly of coiled-coil domain”

    K. Suzuki, T. Mizuno, T. Tanaka

    Nucleic Acids Symp Ser (Oxf), 52, 461 (2008).

2007

  • “Metal-ion-dependent GFP Emission in vivo by Combining a Circularly Permutated GFP with an Engineered Metal Ion Binding Coiled-coil”

    T. Mizuno, K. Murao, Y. Tanabe, M. Oda, T. Tanaka

    J. Am. Chem. Soc., 129, 11378-11383 (2007).

2006

  • “Activating an Enzyme by an Engineered Coiled Coil Switch”

    S. Yuzawa, T. Mizuno, T. Tanaka

    Chem. Eur. J., 12, 7345-7362 (2006).

  • “New Polyethyleneglycol-functionalized Texaphyrins: Synthesis and in vitro Biological Studies”

    W. H. Wei, Z. Wang, T. Mizuno, C. Cortez, L. Fu, M. Sirisawad, L. Naumovski, L. Magda, J. L. Sessler

    Dalton Trans., 16, 1934-1942 (2006).

2005

  • "Extraordinary High Thermal Stability by a Designed Tandem Arg-Trp Stretch in an ?-Helical Coiled-coil"

    Y. Sakurai, T. Mizuno, H. Hiroaki, K. Gohda, J. OKu, T. Tanaka

    Angew. Chem. Int. Ed., 44 (38), 6180-6183 (2005).

  • "Optimization of Aromatic Side Chain Size Complementarity in the Hydrophobic Core of a Designed Coiled-coil"

    Y. Sakurai, T. Mizuno, H. Hiroaki, J. Oku, T. Tanaka

    J. Pep. Res., 66(6), 387-394 (2005).

  • “Design and Expression of Cysteine-Bearing Hydrophobic Polypeptides and Their Self-Assembling Properties with Bacteriochlorophyll a Derivatives as a Mimic of Bacterial Photosynthetic Antenna Complexes. Effect of Steric Confinement and Orientation of the Polypeptides on the Pigment/Polypeptide Assembly Process”

    T. Dewa, T. Yamada, M. Ogawa, M. Sugimoto, T. Mizuno, K. Yoshida, Y. Nakao, M. Kondo, K. Iida, K. Yamashita, T. Tanaka, and M. Nango

    Biochemistry, 44, 5129-5139 (2005).

  • “Photo-control of Aggregate Behavior of Coiled-coil motif Peptides using Azobenzene derivatives”

    K. Fukuda, T. Mizuno, J. Oku, T. Tanaka.

    Peptide Sci., 2004, 619-620 (2005).

2004

  • “Two-Metal Ion, Ni(II) and Cu(II), Binding ?-Helical Coiled-coil Peptide”

    T. Tanaka, T. Mizuno, S. Fukui, H. Hiroaki, J. Oku, K. Kanaori, K. Tajima, M. Shirakawa

    J. Am. Chem. Soc., 126, 14023-14028 (2004).

  • “Selective Formation of AAB- and ABC-type Heterotrimeric ?-Helical Coiled-coils”

    T. Kiyokawa, K. Kanaori, K. Tajima, M. Kawaguchi, T. Mizuno, J. Oku, T. Tanaka

    Chem. Eur. J., 10, 3548-3554 (2004).

  • “Binding of Cu(II) or Zn(II) in a de novo Designed Triple-stranded ?-Helical Coiled-coil toward a Prototype for a Metalloenzyme”

    T. Kiyokawa, K. Kanaori, K. Tajima, M. Koike, T. Mizuno, J. Oku, T. Tanaka.

    J. Pept. Res., 63/4, 347-354 (2004).

  • “Regulation of Protein Expression using Designed ?-Helical Coiled-coil in E. coli.”

    Y. Takeshima, T. Mizuno, J. Oku, T. Tanaka.

    Peptide Sci., 2003, 467-468 (2004).

2003

  • “pH-Induced Conformational Changes in an ?-Helical Coiled-coil is Controlled by His Residues in the Hydrophobic Core”

    K. Wada, T. Mizuno, J. Oku, T. Tanaka

    Protein Peptide Lett., 10, 27-33 (2003).

  • “Design of Dimetal-binding ?-Helical Coiled-coil Peptide”

    M. Koike, K. Wada, T. Kiyokawa, K. Kanaori, K. Tajima, T. Mizuno, J. Oku, T. Tanaka

    Peptide Sci., 2002, 355-356 (2003).

2002

  • “Phenanthroline complexes bearing fused dipyrrolylquinoxaline anion recognition sites: efficient fluoride anion receptors”

    T. Mizuno, W.- H. Wei, E. L. Eller, J. L. Sessler

    J. Am. Chem. Soc., 124, 7, 1134-1135.

  • “Quinoxaline-oligopyrroles: improved pyrrole-based anion receptors”

    J. L. Sessler, H. Maeda, T. Mizuno, V. M. Lynch, H. Furuta

    Chem. Commun., 8, 862-863.

  • “Quinoxaline-bridged porphyrinoids”

    J. L. Sessler, H. Maeda, T. Mizuno, V. M. Lynch, H. Furuta

    J. Am. Chem. Soc., 124, 45, 13474-13479.

ページの先頭へ

特許

  • リポペプチド誘導体を含む抗菌剤

    平成29年5月11日出願、特願2017-094745

    木村亮介、水野稔久、山村初雄、宮川淳

  • 核酸内包繊維状物質を含む構造体の製造方法

    平成27年1月16日出願、特願2015-006431

    水野稔久、小幡亜希子、市来健太郎、岩永憲彦

  • 膜タンパク質可溶化剤

    平成26年5月29日出願、特願2014-110888

    柴田将英、小枝周平、野地智康、出羽毅久、水野稔久

  • タンパク質内包不織布の製造方法,

    平成26年7月11日出願、特願2014-143141

    水野稔久、小幡亜希子、市来健太郎、小枝周平、柴田将英、岩永憲彦

  • 膜タンパク質ゲル化剤

    平成25年7月30日出願、特願2013-157755

    小枝周平、水野稔久、野地智康、小幡亜希子、出羽毅久、春日敏宏

  • 膜タンパク質可溶化剤

    平成24年10月29日出願、特願2012-237380

    小枝周平、梅崎勝成、野地智康、出羽毅久、水野稔久

  • アミノ酸配列含有両親媒性化合物

    平成23年8月11日出願、特願2011-175682

    水野稔久、梅崎勝成、小枝周平

  • 色素修飾液晶分子及び色素修飾液晶分子利用の材料

    平成19年9月6日出願、特願2007-230945

    水野稔久、杉山雄蔵、猪股克弘、田中俊樹

  • 構造転移ペプチド

    平成19年9月10日出願、特願2007-233589

  • 金属イオン応答性蛍光発色タンパク質

    平成18年10月12日出願、特願2006-247008

    平成25年1月25日登録、特許第5181170号

    水野稔久、村尾香織、田中俊樹

  • 人工タンパク質複合体及びその利用

    平成17年9月2日出願、特願2005-255526

    南後守、出羽毅久、山下啓司、田中俊樹、水野稔久、永島賢治、永島咲子

  • 酸性条件で膜融合を促進するペプチド誘導体

    平成16年7月31日出願、特願2004-221366

    田中俊樹、水野稔久

  • クロロフィル誘導体の二量体及びその金属錯体、及び当該化合物を触媒として用いた有機化合物の酸化方法

    平成16年11月30日出願、特願2004-345081

    南後守、出羽毅久、山下啓司、田中俊樹、水野稔久、橋本貴史

ページの先頭へ

書籍

2004

  • “2,3-Dipyrrolylquinoxaline-based Anion Sensors”

    J. L. Sessler, B. Andrioletti, P. Anzenbacher, Jr., C. Black, L. Eller, H. Furuta, K.Jursikova, H. Maeda, M. Marquez, T. Mizuno, A. Try

    Fundamentals and applications of anion separations, p.71-85 (2004)

総説

2017

  • 「生理活性を保持した不織布の開発」

    水野稔久、小幡亜希子

    月刊ファインケミカル，2017年７月号

2015

  • 「生理活性を保持した不織布の開発」

    水野稔久、小幡亜希子

    ケミカルエンジニヤリング, 2015年12月号

2011

  • 「異なる機能を持った蛋白質ドメインの組み合わ せによる刺激応答性蛋白質の合理的設計」

    水野稔久

    化学と教育, 59, 212-213 (2011)

2008

  • 「設計タンパク質をモジュールドメインとして利 用した外部刺激応答タンパク質の創製」

    水野稔久、織田昌幸、田中俊樹

    熱測定, 35(5), 227-236 (2008)

ページの先頭へ