Dewa・Kondo Lab.
Professor Takehisa DEWA
Department of Life Science and Applied Chemistry
Graduate School of Engineering
Nagoya Institute of Technology
Room320,Bidg19
Gokiso-cho, Showa, Nagoya,466-8555 Japan
takedewa*nitech.ac.jp(*=@)
Phone:+81-52-735-5144｜Web
Affiliation
Department of Life Science and Applied Chemistry
Academic Degree
Doctor of Engineering (Tokyo Institute of Technology, 1994)
Academic background
| 1994 | Department of Polymer Chemistry, Graduate School of Engineering, Tokyo Institute of Technology |
| 1994–1996 | Postdoctoral fellow, Lehigh University, USA (Professor Steven L. Regen) |
| 1996–2000 | Postdoctoral fellow, Kyushu University, Japan (CREST/JST, Professor Yasuhiro Aoyama) |
| 2001–2004 | Assistant Professor, Nagoya Institute of Technology |
| 2001–2005 | PRESTO Researcher (Organization and Function, JST) |
| 2004–2008 | Lecturer, Nagoya Institute of Technology |
| 2008–2016 | Associate Professor, Nagoya Institute of Technology |
| 2009-2013 | PRESTO Researcher (Chemical Conversion of Light Energy, JST) |
| 2016-present | Professor, Nagoya Institute of Technology |
Research Interests
- Structure and function of biomolecular assemblies
- Construction and functional analysis of photosynthetic antenna systems
- Drug delivery systems using synthetic lipids
Membership
American Chemical Society, The Chemical Society of Japan, The Society of
Polymer Science,
The Biophysical Society of Japan, The Japanese Society of Photosunthesis
Research
Selected Publications(2010-Present)
- Enhanced Light Harvesting and Photocurrent Generation Activities of Biohybrid
Light–harvesting 1–Reaction Center Core Complexes (LH1-RCs) from Rhodopseudomonas
palustris
Genki Kasagi, Yusuke Yoneda, Masaharu Kondo, Hiroshi Miyasaka, Yutaka Nagasawa, Takehisa Dewa
J. Photochem. Photobiol. A: Chemistry, in press - Ultrafast Photodynamics and Quantitative Evaluation of Biohybrid Photosynthetic
Antenna and Reaction Center Complexes Generating Photocurrent
Y. Yoneda, A. Goto, N. Takeda, H. Harada, M. Kondo, H. Miyasaka, Y. Nagasawa, T. Dewa
J. Phys. Chem. C 124, 8605-8615 (2020) - Sequential Energy Transfer Driven by Monoexponential Dynamics in a Biohybrid
Light–Harvesting Complex 2 (LH2)
Y. Yoneda, D. Kato, M. Kondo, K. V. P. Nagashima, H. Miyasaka, Y. Nagasawa, T. Dewa
Photosynth. Res. 143, 115-128 (2020) - Key determinants of siRNA delivery mediated by unique pH-responsive lipid-based
liposomes
Sako M, Song F, Okamoto A, Koide H, Dewa T, Oku N, Asai T
Int. J Pharm. 569, 118606 (2019) - Engineering the binding kinetics of synthetic polymer nanoparticles for
siRNA delivery
H. Koide, T. Fukuta, A. Okishim, S. Ariizumi, C. Kiyokawa, H. Tsuchida, M. Nakamoto, K. Yoshimatsu, H. Ando, T. Dewa, T. Asai, N. Oku, Y. Hoshino, K. J. Shea
Biomacromolecules 20, 3648–3657 (2019) - Rigorous control of vesicle-forming lipid pKa by fluorine-conjugated bioisosteres
for gene-silencing with siRNA
A. Okamoto, H. Koide, N. Morita, Y. Hirai, Y. Kawato, H. Egami, Y. Hamashima, T. Asai, T. Dewa, N. Oku
J. Control. Release 295, 87-92 (2019) - Design of a Novel PEGylated Liposomal Vector for Systemic Delivery of siRNA
to Solid Tumors
F. Song, N. Sakurai, A. Okamoto, H. Koide, N. Oku, T. Dewa, T. Asai
Biol. Pharm. Bull. 42, 996–1003 (2019) - Photovoltaic Action in Graphene-Ga2O3 Heterojunction with Deep-Ultraviolet
Irradiation
G. Kalita, R. D. Mahyavanshi, P. Desai, A. K. Ranade, M. Kondo, T. Dewa, M. Tanemura
Phys. Status Solidi RRL 2018, 12, 1800198 (May 30, 2018) - Selective immobilization of bacterial light-harvesting proteins and their
photoelectric responses
R. Furukawa, M. Kondo, S. Yajima, K. Harada, K. V. P. Nagashima, M. Nagata, K. Iida, T. Dewa, M. Nango
MRS Communications 8, (3), 1124-1128 (2018) - Photovoltaic action with broad band photoresponsivity in germanium-MoS2
ultrathin heterojunction
R. D. Mahyavanshi, G. Kalita, A. Ranade, P. Desai, M. Kondo, T. Dewa, M. Tanemura
IEEE Transactions on Electron Devices, 65, 4434-4440 (2018) - Lipid-Controlled Stabilization of Charge-Separated States (P+QB–) and Photocurrent
Generation Activity of a Light-Harvesting–Reaction Center Core Complex
(LH1-RC) from Rhodopseudomonas palustris
T. Noji, M. Matsuo, N. Takeda, A. Sumino, M. Kondo, M. Nango, S. Itoh, T. Dewa
J. Phys. Chem. B 122, 1066–1080 (2018) - Synthesis of MoS2 ribbons and their branched structures by chemical vapor
deposition in sulfur enriched environment
Mahyavanshi, R. D.; Kalita, G.; Sharma, K. P.; Kondo, M.; Dewa, T.; Kawahara, T.; Tanemura, M
Appl. Surf. Sci. 409, 396-402 (2017) - Encapsulation of transition metal dichalcogenides crystals with room temperature
plasma deposited carbonaceous films
Mahyavanshi, Rakesh D.; Kalita, Golap; Singh, Rupesh; Kondo, Masaharu; Dewa, Takehisa; Kawahara, Toshio; Umeno, Masayoshi; Tanemura, Masaki
RSC Adv. 7, 41136-41143 (2017) - Non-RVD mutations that enhance the dynamics of the TAL repeat array along
the superhelical axis improve TALEN genome editing efficacy
Naoya Tochio, Kohei Umehara, Jun-ichi Uewaki, Holger Flechsig, Masaharu Kondo, Takehisa Dewa, Tetsushi Sakuma, Takashi Yamamoto, Takashi Saitoh, Yuichi Togashi, Shin-ichi Tate
Scientific Reports 2016, 6, 37887 (1-12) - Morphological Observation of Specific Condensation Effect of Cholesterol
on Dipalmitoyl Phosphatidyl Choline (DPPC) Monolayer by Dropping Method
Y. Yokoyama, D. Yoshida, H. Mori, M. Okabe, Z. Shervani, K. Taga, Y. Yamamoto, A. Sumino, T. Dewa, M. Nango, M. Yamamoto
J. Biophys. Chem. 7, 98–109 (2016) - Oxygen-Evolving Porous Glass Plates Containing the Photosynthetic Photosystem
II Pigment-Protein Complex
T. Noji, K. Kawakami, J. R. Shen, T. Dewa, M. Nango, N. Kamiya, S. Itoh, T. Jin
Langmuir, 32, 7796–7805, 2016 - Design of New Extraction Surfactants for Membrane Proteins from Peptide
Gemini Surfactants
M. Shibata, S. Koeda, T. Noji, K. Kawakami, Y. Ido, Y. Amano, N. Umezawa, T. Higuchi, T. Dewa, S. Itoh, N. Kamiya, T. Mizuno
Bioconjugate Chem., 27 (10) 2469-2479 (2016) - Rational design of novel high molecular weight solubilization surfactants
for membrane proteins from the peptide Gemini surfactants (PG-surfactants)
S. Koeda, T. Suzuki, T. Noji, K. Kawakami, S. Itoh, T. Dewa, N. Kamiya, T. Mizuno
Tetrahedron 72, 6898–6908 (2016) - Light-induced hydrogen production by Photosystem I–Pt nanoparticle conjugates
immobilized in porous glass plate nanopores
T. Noji, T. Suzuki, M. Kondo, T. Jin, K. Kawakami, T. Mizuno, H. Oh-oka, M. Ikeuchi, M. Nango, Y. Amao, N. Kamiya, T. Dewa
Res. Chem. Intermed. 42 (11) 7731-7742 (2016) - Light-energy conversion systems for hydrogen production and photocurrent
generation using zinc chlorin derivatives
S. Ishigure, M. Kondo, T. Dewa, Y. Amao, M. Nango
Res. Chem. Intermed. 42 (11) 7743-7752 (2016) - Enhanced efficacy of doxorubicin by microRNA-499-mediated improvement of
tumor blood flow
Ayaka Okamoto, Tomohiro Asai, Sho Ryu, Hidenori Ando, Noriyuki Maeda, Takehisa Dewa, Naoto Oku
Clinical Medicine 5, 10-18 (2016) - Light-induced hydrogen production by Photosystem I–Pt nanoparticle conjugates
immobilized in porous glass plate nanopores
T. Noji, T. Suzuki, M. Kondo, T. Jin, K. Kawakami, T. Mizuno, H. Oh-oka, M. Ikeuchi, M. Nango, Y. Amao, N. Kamiya, T. Dewa
Res. Chem. Intermed. 42 (11) 7731-7742 (2016) - One-step encapsulation of siRNA between lipid-layers of multi-layer polycation
liposomes by lipoplex freeze-thawing
H. Koide, A. Okamoto, H. Tsuchida, H. Ando, S. Ariizumi, C. Kiyokawa, M. Hashimoto, T. Asai, T. Dewa, N. Oku
J. Controlled Release 228, 1-8 2016 - Extension of Light-Harvesting Ability of Photosynthetic Light-Harvesting
Complex 2 (LH2) through Ultrafast Energy Transfer from Covalently Attached
Artificial Chromophores
Y. Yoneda, T. Noji, T. Katayama, N. Mizutani, D. Komori, M. Nango, H. Miyasaka, S. Itoh, Y. Nagasawa, T. Dewa
J. Am. Chem. Soc., 137, 13121-13129 (2015) - Advanced cancer therapy by integrative antitumor actions via systemic administration
of miR-499
H. Ando, T. Asai, H. Koide, A. Okamoto, N. iMaeda, K. Tomita, T. Dewa, T. Minamino, N. Oku
J. Controlled Release 181, 32-39 (2014) - Light-driven Hydrogen Production by Hydrogenases and a Ru-complex inside
a Nanoporous Glass Plate under Aerobic External Conditions
T. Noji, M. Kondo, T. Jin, T. Yazawa, H. Osuka, Y. Higuchi, M. Nango, S. Itoh, T. Dewa
J. Phys. Chem. Lett. 5, 2402–2407 (2014) - Gating-Associated Clustering−Dispersion Dynamics of the KcsA Potassium
Channel in a Lipid Membrane
A. Sumino, D. Yamamoto, M. Iwamoto, T. Dewa, S. Oiki
J. Phys. Chem. Lett. 5, 578-584 (2014) - Structure–Function Relationships of the Supramolecular Assembly of the
Bacterial Photosynthetic Antenna Complexes in Lipid Membranes
T. Dewa, A. Sumino, N. Watanabe, T. Noji, M. Nango
Res. Chem. Intermed. 40, 3243-3256 (2014) - Influence of Phospholipid Composition on Self-Assembly and Energy-Transfer
Efficiency in Networks of Light-Harvesting 2 Complexes
A. Sumino, T. Dewa, T. Noji, Y. Nakano, N. Watanabe, R. Hildner, N. Bösch, J. Köhler, M. Nango
J. Phys. Chem. B 117, 10395–10404 (2013) - Electron Conduction and Photocurrent Generation of a Light-Harvesting/Reaction
Center Core Complex in Lipid Membrane Environments
A. Sumino, T. Dewa, N. Sasaki, M. Kondo, M. Nango
J. Phys. Chem. Lett. 4, 1087–1092 (2013) - Energy Transfer and Clustering of Photosynthetic Light-Harvesting Complexes
in Reconstituted Lipid Membranes
T. Dewa, A. Sumino, N. Watanabe, T. Noji, M. Nango
Chem. Phys., 419, 200-204 (2013) - The Open Gate Structure of the Membrane-Embedded KcsA Potassium Channel
Viewed From the Cytoplasmic Side
A. Sumino, T. Sumikama, M. Iwamoto, T. Dewa, S. Oiki
Scientific Reports 3, 1063 (2013) - Immobilization and Photocurrent Activity of a Light-Harvesting Antenna
Complex II, LHCII Isolated from a Plant on Electrodes
M. Nagata, M. Amano, T. Joke, K. Fuji, A. Okuda, M. Kondo, S. Ishigure, T. Dewa, K. Iida, F. Secundo, Y. Amao, H. Hashimoto, M. Nango
ACS Macro Lett., 1, 296-299 (2012) - RGD-based active targeting of novel polycation liposomes bearing siRNA
for cancer treatment
N. Yonenaga, E. Kenjo, T. Asai, A. Tsuruta, K. Shimizu, T. Dewa, M. Nango, N. Oku
J. Control. Release 160, 177-181 (2012) - Construction and Structural Analysis of Tethered Lipid Bilayer Containing
Photosynthetic Antenna Proteins for Functional Analysis
A. Sumino, T. Dewa, T. Takeuchi, R. Sugiura, N. Sasaki, N. Misawa, R. Tero, T. Urisu, A. T. Gardiner, R. J. Cogdell, H. Hashimoto, M. Nango
Biomacromolecules, 12, 2850-2858 (2011) - Dicetyl phosphate-tetraethylenepentamine-based Liposomes for Systemic siRNA
Delivery
T. Asai, S. Matsushita, E. Kenjo, T. Tsuzuku, N. Yonenaga, H. Koide, K. Hatanaka, T. Dewa, M. Nango, N. Maeda, H. Kikuchi, N. Oku
Bioconjugate Chem. 22 429-435 (2011) - Reconstitution and AFM Observation of Photosynthetic Membrane Protein Assembly
in Planar Lipid Bilayers
A. Sumino, T. Dewa, N. Sasaki, N. Watanabe, M. Kondo, T. Morii, H. Hashimoto, M. Nango
e-J. Surf. Sci. Nanotech. 9, 15-20 (2011) (Editor’s choice) - Selective Assembly of Photosynthetic Antenna Proteins into a Domain-Structured
Lipid Bilayer for the Construction of Artificial Photosynthetic Antenna
Systems: Structural Analysis of the Assembly using Surface Plasmon Resonance
and Atomic Force Microscopy
A. Sumino, T. Dewa, M. Kondo, T. Morii, H. Hashimoto, A. T. Gardiner, R. J. Cogdell, M. Nango
Langmuir, 27, 1092-1099 (2011) - Liposomal Polyamine–Dialkyl Phosphate Conjugates as Effective Gene Carriers:
Chemical Structure, Morphology, and Gene Transfer activity
T. Dewa, T. Asai, Y. Tsunoda, K. Kato, D. Baba, M. Uchida, A. Sumino, K. Niwata, T. Umemoto, K. Iida, N. Oku, M. Nango
Bioconjugate Chem., 21, 844-852 (2010)
