Dewa・Kondo Lab.

Professor  Takehisa DEWA

Takehisa DEWA

Department of Life Science and Applied Chemistry
Graduate School of Engineering
Nagoya Institute of Technology

Room320,Bidg19
Gokiso-cho, Showa, Nagoya,466-8555 Japan
takedewa*nitech.ac.jp(*=@)
Phone:+81-52-735-5144|Web

Affiliation

Department of Life Science and Applied Chemistry

Academic Degree

Doctor of Engineering (Tokyo Institute of Technology, 1994)

Academic background

1994 Department of Polymer Chemistry, Graduate School of Engineering, Tokyo Institute of Technology
1994–1996 Postdoctoral fellow, Lehigh University, USA (Professor Steven L. Regen)
1996–2000 Postdoctoral fellow, Kyushu University, Japan (CREST/JST, Professor Yasuhiro Aoyama)
2001–2004 Assistant Professor, Nagoya Institute of Technology
2001–2005 PRESTO Researcher (Organization and Function, JST)
2004–2008 Lecturer, Nagoya Institute of Technology
2008–2016 Associate Professor, Nagoya Institute of Technology
2009-2013 PRESTO Researcher (Chemical Conversion of Light Energy, JST)
2016-present Professor, Nagoya Institute of Technology

Research Interests

  • Structure and function of biomolecular assemblies
  • Construction and functional analysis of photosynthetic antenna systems
  • Drug delivery systems using synthetic lipids

Membership

American Chemical Society, The Chemical Society of Japan, The Society of Polymer Science,
The Biophysical Society of Japan, The Japanese Society of Photosunthesis Research

Selected Publications(2010-Present)

Link to NIT webpage

  • Enhanced Light Harvesting and Photocurrent Generation Activities of Biohybrid Light–harvesting 1–Reaction Center Core Complexes (LH1-RCs) from Rhodopseudomonas palustris
    Genki Kasagi, Yusuke Yoneda, Masaharu Kondo, Hiroshi Miyasaka, Yutaka Nagasawa, Takehisa Dewa
    J. Photochem. Photobiol. A: Chemistry, in press
  • Ultrafast Photodynamics and Quantitative Evaluation of Biohybrid Photosynthetic Antenna and Reaction Center Complexes Generating Photocurrent
    Y. Yoneda, A. Goto, N. Takeda, H. Harada, M. Kondo, H. Miyasaka, Y. Nagasawa, T. Dewa
    J. Phys. Chem. C 124, 8605-8615 (2020)
  • Sequential Energy Transfer Driven by Monoexponential Dynamics in a Biohybrid Light–Harvesting Complex 2 (LH2)
    Y. Yoneda, D. Kato, M. Kondo, K. V. P. Nagashima, H. Miyasaka, Y. Nagasawa, T. Dewa
    Photosynth. Res. 143, 115-128 (2020)
  • Key determinants of siRNA delivery mediated by unique pH-responsive lipid-based liposomes
    Sako M, Song F, Okamoto A, Koide H, Dewa T, Oku N, Asai T
    Int. J Pharm. 569, 118606 (2019)
  • Engineering the binding kinetics of synthetic polymer nanoparticles for siRNA delivery
    H. Koide, T. Fukuta, A. Okishim, S. Ariizumi, C. Kiyokawa, H. Tsuchida, M. Nakamoto, K. Yoshimatsu, H. Ando, T. Dewa, T. Asai, N. Oku, Y. Hoshino, K. J. Shea
    Biomacromolecules 20, 3648–3657 (2019)
  • Rigorous control of vesicle-forming lipid pKa by fluorine-conjugated bioisosteres for gene-silencing with siRNA
    A. Okamoto, H. Koide, N. Morita, Y. Hirai, Y. Kawato, H. Egami, Y. Hamashima, T. Asai, T. Dewa, N. Oku
    J. Control. Release 295, 87-92 (2019)
  • Design of a Novel PEGylated Liposomal Vector for Systemic Delivery of siRNA to Solid Tumors
    F. Song, N. Sakurai, A. Okamoto, H. Koide, N. Oku, T. Dewa, T. Asai
    Biol. Pharm. Bull. 42, 996–1003 (2019)
  • Photovoltaic Action in Graphene-Ga2O3 Heterojunction with Deep-Ultraviolet Irradiation
    G. Kalita, R. D. Mahyavanshi, P. Desai, A. K. Ranade, M. Kondo, T. Dewa, M. Tanemura
    Phys. Status Solidi RRL 2018, 12, 1800198 (May 30, 2018)
  • Selective immobilization of bacterial light-harvesting proteins and their photoelectric responses
    R. Furukawa, M. Kondo, S. Yajima, K. Harada, K. V. P. Nagashima, M. Nagata, K. Iida, T. Dewa, M. Nango
    MRS Communications 8, (3), 1124-1128 (2018)
  • Photovoltaic action with broad band photoresponsivity in germanium-MoS2 ultrathin heterojunction
    R. D. Mahyavanshi, G. Kalita, A. Ranade, P. Desai, M. Kondo, T. Dewa, M. Tanemura
    IEEE Transactions on Electron Devices, 65, 4434-4440 (2018)
  • Lipid-Controlled Stabilization of Charge-Separated States (P+QB–) and Photocurrent Generation Activity of a Light-Harvesting–Reaction Center Core Complex (LH1-RC) from Rhodopseudomonas palustris
    T. Noji, M. Matsuo, N. Takeda, A. Sumino, M. Kondo, M. Nango, S. Itoh, T. Dewa
    J. Phys. Chem. B 122, 1066–1080 (2018)
  • Synthesis of MoS2 ribbons and their branched structures by chemical vapor deposition in sulfur enriched environment
    Mahyavanshi, R. D.; Kalita, G.; Sharma, K. P.; Kondo, M.; Dewa, T.; Kawahara, T.; Tanemura, M
    Appl. Surf. Sci. 409, 396-402 (2017)
  • Encapsulation of transition metal dichalcogenides crystals with room temperature plasma deposited carbonaceous films
    Mahyavanshi, Rakesh D.; Kalita, Golap; Singh, Rupesh; Kondo, Masaharu; Dewa, Takehisa; Kawahara, Toshio; Umeno, Masayoshi; Tanemura, Masaki
    RSC Adv. 7, 41136-41143 (2017)
  • Non-RVD mutations that enhance the dynamics of the TAL repeat array along the superhelical axis improve TALEN genome editing efficacy
    Naoya Tochio, Kohei Umehara, Jun-ichi Uewaki, Holger Flechsig, Masaharu Kondo, Takehisa Dewa, Tetsushi Sakuma, Takashi Yamamoto, Takashi Saitoh, Yuichi Togashi, Shin-ichi Tate
    Scientific Reports 2016, 6, 37887 (1-12)
  • Morphological Observation of Specific Condensation Effect of Cholesterol on Dipalmitoyl Phosphatidyl Choline (DPPC) Monolayer by Dropping Method
    Y. Yokoyama, D. Yoshida, H. Mori, M. Okabe, Z. Shervani, K. Taga, Y. Yamamoto, A. Sumino, T. Dewa, M. Nango, M. Yamamoto
    J. Biophys. Chem. 7, 98–109 (2016)
  • Oxygen-Evolving Porous Glass Plates Containing the Photosynthetic Photosystem II Pigment-Protein Complex
    T. Noji, K. Kawakami, J. R. Shen, T. Dewa, M. Nango, N. Kamiya, S. Itoh, T. Jin
    Langmuir, 32, 7796–7805, 2016
  • Design of New Extraction Surfactants for Membrane Proteins from Peptide Gemini Surfactants
    M. Shibata, S. Koeda, T. Noji, K. Kawakami, Y. Ido, Y. Amano, N. Umezawa, T. Higuchi, T. Dewa, S. Itoh, N. Kamiya, T. Mizuno
    Bioconjugate Chem., 27 (10) 2469-2479 (2016)
  • Rational design of novel high molecular weight solubilization surfactants for membrane proteins from the peptide Gemini surfactants (PG-surfactants)
    S. Koeda, T. Suzuki, T. Noji, K. Kawakami, S. Itoh, T. Dewa, N. Kamiya, T. Mizuno
    Tetrahedron 72, 6898–6908 (2016)
  • Light-induced hydrogen production by Photosystem I–Pt nanoparticle conjugates immobilized in porous glass plate nanopores
    T. Noji, T. Suzuki, M. Kondo, T. Jin, K. Kawakami, T. Mizuno, H. Oh-oka, M. Ikeuchi, M. Nango, Y. Amao, N. Kamiya, T. Dewa
    Res. Chem. Intermed. 42 (11) 7731-7742 (2016)
  • Light-energy conversion systems for hydrogen production and photocurrent generation using zinc chlorin derivatives
    S. Ishigure, M. Kondo, T. Dewa, Y. Amao, M. Nango
    Res. Chem. Intermed. 42 (11) 7743-7752 (2016)
  • Enhanced efficacy of doxorubicin by microRNA-499-mediated improvement of tumor blood flow
    Ayaka Okamoto, Tomohiro Asai, Sho Ryu, Hidenori Ando, Noriyuki Maeda, Takehisa Dewa, Naoto Oku
    Clinical Medicine 5, 10-18 (2016)
  • Light-induced hydrogen production by Photosystem I–Pt nanoparticle conjugates immobilized in porous glass plate nanopores
    T. Noji, T. Suzuki, M. Kondo, T. Jin, K. Kawakami, T. Mizuno, H. Oh-oka, M. Ikeuchi, M. Nango, Y. Amao, N. Kamiya, T. Dewa
    Res. Chem. Intermed. 42 (11) 7731-7742 (2016)
  • One-step encapsulation of siRNA between lipid-layers of multi-layer polycation liposomes by lipoplex freeze-thawing
    H. Koide, A. Okamoto, H. Tsuchida, H. Ando, S. Ariizumi, C. Kiyokawa, M. Hashimoto, T. Asai, T. Dewa, N. Oku
    J. Controlled Release 228, 1-8 2016
  • Extension of Light-Harvesting Ability of Photosynthetic Light-Harvesting Complex 2 (LH2) through Ultrafast Energy Transfer from Covalently Attached Artificial Chromophores
    Y. Yoneda, T. Noji, T. Katayama, N. Mizutani, D. Komori, M. Nango, H. Miyasaka, S. Itoh, Y. Nagasawa, T. Dewa
    J. Am. Chem. Soc., 137, 13121-13129 (2015)
  • Advanced cancer therapy by integrative antitumor actions via systemic administration of miR-499
    H. Ando, T. Asai, H. Koide, A. Okamoto, N. iMaeda, K. Tomita, T. Dewa, T. Minamino, N. Oku
    J. Controlled Release 181, 32-39 (2014)
  • Light-driven Hydrogen Production by Hydrogenases and a Ru-complex inside a Nanoporous Glass Plate under Aerobic External Conditions
    T. Noji, M. Kondo, T. Jin, T. Yazawa, H. Osuka, Y. Higuchi, M. Nango, S. Itoh, T. Dewa
    J. Phys. Chem. Lett. 5, 2402–2407 (2014)
  • Gating-Associated Clustering−Dispersion Dynamics of the KcsA Potassium Channel in a Lipid Membrane
    A. Sumino, D. Yamamoto, M. Iwamoto, T. Dewa, S. Oiki
    J. Phys. Chem. Lett. 5, 578-584 (2014)
  • Structure–Function Relationships of the Supramolecular Assembly of the Bacterial Photosynthetic Antenna Complexes in Lipid Membranes
    T. Dewa, A. Sumino, N. Watanabe, T. Noji, M. Nango
    Res. Chem. Intermed. 40, 3243-3256 (2014)
  • Influence of Phospholipid Composition on Self-Assembly and Energy-Transfer Efficiency in Networks of Light-Harvesting 2 Complexes
    A. Sumino, T. Dewa, T. Noji, Y. Nakano, N. Watanabe, R. Hildner, N. Bösch, J. Köhler, M. Nango
    J. Phys. Chem. B 117, 10395–10404 (2013)
  • Electron Conduction and Photocurrent Generation of a Light-Harvesting/Reaction Center Core Complex in Lipid Membrane Environments
    A. Sumino, T. Dewa, N. Sasaki, M. Kondo, M. Nango
    J. Phys. Chem. Lett. 4, 1087–1092 (2013)
  • Energy Transfer and Clustering of Photosynthetic Light-Harvesting Complexes in Reconstituted Lipid Membranes
    T. Dewa, A. Sumino, N. Watanabe, T. Noji, M. Nango
    Chem. Phys., 419, 200-204 (2013)
  • The Open Gate Structure of the Membrane-Embedded KcsA Potassium Channel Viewed From the Cytoplasmic Side
    A. Sumino, T. Sumikama, M. Iwamoto, T. Dewa, S. Oiki
    Scientific Reports 3, 1063 (2013)
  • Immobilization and Photocurrent Activity of a Light-Harvesting Antenna Complex II, LHCII Isolated from a Plant on Electrodes
    M. Nagata, M. Amano, T. Joke, K. Fuji, A. Okuda, M. Kondo, S. Ishigure, T. Dewa, K. Iida, F. Secundo, Y. Amao, H. Hashimoto, M. Nango
    ACS Macro Lett., 1, 296-299 (2012)
  • RGD-based active targeting of novel polycation liposomes bearing siRNA for cancer treatment
    N. Yonenaga, E. Kenjo, T. Asai, A. Tsuruta, K. Shimizu, T. Dewa, M. Nango, N. Oku
    J. Control. Release 160, 177-181 (2012)
  • Construction and Structural Analysis of Tethered Lipid Bilayer Containing Photosynthetic Antenna Proteins for Functional Analysis
    A. Sumino, T. Dewa, T. Takeuchi, R. Sugiura, N. Sasaki, N. Misawa, R. Tero, T. Urisu, A. T. Gardiner, R. J. Cogdell, H. Hashimoto, M. Nango
    Biomacromolecules, 12, 2850-2858 (2011)
  • Dicetyl phosphate-tetraethylenepentamine-based Liposomes for Systemic siRNA Delivery
    T. Asai, S. Matsushita, E. Kenjo, T. Tsuzuku, N. Yonenaga, H. Koide, K. Hatanaka, T. Dewa, M. Nango, N. Maeda, H. Kikuchi, N. Oku
    Bioconjugate Chem. 22 429-435 (2011)
  • Reconstitution and AFM Observation of Photosynthetic Membrane Protein Assembly in Planar Lipid Bilayers
    A. Sumino, T. Dewa, N. Sasaki, N. Watanabe, M. Kondo, T. Morii, H. Hashimoto, M. Nango
    e-J. Surf. Sci. Nanotech. 9, 15-20 (2011) (Editor’s choice)
  • Selective Assembly of Photosynthetic Antenna Proteins into a Domain-Structured Lipid Bilayer for the Construction of Artificial Photosynthetic Antenna Systems: Structural Analysis of the Assembly using Surface Plasmon Resonance and Atomic Force Microscopy
    A. Sumino, T. Dewa, M. Kondo, T. Morii, H. Hashimoto, A. T. Gardiner, R. J. Cogdell, M. Nango
    Langmuir, 27, 1092-1099 (2011)
  • Liposomal Polyamine–Dialkyl Phosphate Conjugates as Effective Gene Carriers: Chemical Structure, Morphology, and Gene Transfer activity
    T. Dewa, T. Asai, Y. Tsunoda, K. Kato, D. Baba, M. Uchida, A. Sumino, K. Niwata, T. Umemoto, K. Iida, N. Oku, M. Nango
    Bioconjugate Chem., 21, 844-852 (2010)
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